| Bioactivity | Rauwolscine is a selective α2-adrenoceptor antagonist that inhibits tumor growth and induces apoptosis[1]. |
| In Vivo | Rauwolscine (0.5 mg/kg, daily) 通过增强细胞凋亡和减少细胞增殖来减少 Balb/c 雌性小鼠的肿瘤生长[1]。Rauwolscine (i.v., 2.24 mg/kg) 能明显释放大鼠的舔食冲突反应，类似于α受体激动剂 clonidine (0.022 mg/kg) 和benzodiazepine diazepam (0.5 mg/kg)[2]。 |
| Name | Rauwolscine |
| CAS | 131-03-3 |
| Formula | C21H26N2O3 |
| Molar Mass | 354.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. A Bruzzone, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008 Oct;155(4):494-504. [2]. S La Marca, et al. The alpha-2 antagonists idazoxan and rauwolscine but not yohimbine or piperoxan are anxiolytic in the Vogel lick-shock conflict paradigm following intravenous administration. Life Sci. 1994;54(10):PL179-84. |