| Bioactivity | Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site partial agonist. Target: NMDARapastinel is a robust cognitive enhancer and facilitates hippocampal long-term potentiation (LTP) of synaptic transmission in slices. | |||||||||
| Name | Rapastinel | |||||||||
| CAS | 117928-94-6 | |||||||||
| Sequence | Thr-Pro-Pro-Thr-NH2 | |||||||||
| Shortening | TPPT-NH2 | |||||||||
| Formula | C18H31N5O6 | |||||||||
| Molar Mass | 413.47 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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| Reference | [1]. Burgdorf J, et al. The long-lasting antidepressant effects of rapastinel (GLYX-13) are associated with a metaplasticity process in the medial prefrontal cortex and hippocampus. Neuroscience. 2015 Nov 12;308:202-11. |
Rapastinel
CAS: 117928-94-6 F: C18H31N5O6 W: 413.47
Rapastinel (GLYX-13) is an N-methyl-D-aspartate receptor (NMDAR) modulator that has characteristics of a glycine site pa
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