| Bioactivity | Rapamycin (Sirolimus) GMP Like is Rapamycin (HY-10219) produced by using GMP like guidelines. GMP Like small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Rapamycin is a potent and specific mTOR inhibitor[1][2][3]. |
| Invitro | Rapamycin GMP Like（1 nM；2-3 周）可诱导人胚胎干细胞 (hESC) 体外分化为矿化成骨细胞[1]。Rapamycin GMP Like（1 nM；2-3 周）可增强人胚状体 (hEB) 的成骨细胞分化[1]。Rapamycin GMP Like（20 nM；4 小时）血清依赖性促进血管平滑肌细胞 (VSMC) 分化[2]。Rapamycin GMP Like 诱导大鼠成骨样骨肉瘤细胞中的成骨细胞分化[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Rapamycin (GMP Like) 相关抗体: |
| CAS | 53123-88-9 |
| Formula | C51H79NO13 |
| Molar Mass | 914.17 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lee KW, et al. Rapamycin promotes the osteoblastic differentiation of human embryonic stem cells by blocking the mTOR pathway and stimulating the BMP/Smad pathway. Stem Cells Dev. 2010 Apr;19(4):557-68. [2]. Martin KA, et al. Rapamycin promotes vascular smooth muscle cell differentiation through insulin receptor substrate-1/phosphatidylinositol 3-kinase/Akt2 feedback signaling. J Biol Chem. 2007 Dec 7;282(49):36112-20. [3]. Ogawa T, et al. Osteoblastic differentiation is enhanced by rapamycin in rat osteoblast-like osteosarcoma (ROS 17/2.8) cells. Biochem Biophys Res Commun. 1998 Aug 10;249(1):226-30. |
Rapamycin (GMP Like)
CAS: 53123-88-9 F: C51H79NO13 W: 914.17
Rapamycin (Sirolimus) GMP Like is Rapamycin (HY-10219) produced by using GMP like guidelines. GMP Like small molecules w
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