Rabeprazole-d4 potassium

CAS: F: C18H16D4KN3O3S W: 401.56

Rabeprazole-d4 potassium is deuterated labeled Rabeprazole sodium (HY-B0656A). Rabeprazole sodium (LY307640 sodium) is a

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Bioactivity	Rabeprazole-d4 potassium is deuterated labeled Rabeprazole sodium (HY-B0656A). Rabeprazole sodium (LY307640 sodium) is a second-generation proton pump inhibitor (PPI) that irreversibly inactivates gastric H+/K+-ATPase. Rabeprazole sodium induces apoptosis. Rabeprazole sodium acts as an uridine nucleoside ribohydrolase (UNH) inhibitor with an IC50 of 0.3 μM. Rabeprazole sodium can be used for the research of gastric ulcerations and gastroesophageal reflux[1][2][3].
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。Rabeprazole 在用 0.2 mM 处理 16 小时后减弱人胃癌细胞的细胞活力[3]。 Rabeprazole 完全抑制 MKN-28 细胞中 ERK1/2 的磷酸化。胃癌细胞系 MKN-28 在酸性培养基 (pH 5.4) 中培养 2 小时，用 Rabeprazole (0.2 mM，持续 2 小时) 预处理可强烈抑制 MKN-28 细胞中的 ERK 1/2 磷酸化[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Rabeprazole-d4 potassium 相关抗体:
In Vivo	Rabeprazole sodium (10 mg/kg；口服每 48 小时一次，持续 18 周) 疗程导致雌性小鼠骨密度 (BMD) 显著下降并降低血清钙水平并产生继发性甲状旁腺功能亢进症[4]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Formula	C18H16D4KN3O3S
Molar Mass	401.56
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Aly A M Shaalan, et al. Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels. Front Pharmacol. 2020 May 13;11:583. [3]. Tara A Shea, et al. Identification of Proton-Pump Inhibitor Drugs That Inhibit Trichomonas Vaginalis Uridine Nucleoside Ribohydrolase. Bioorg Med Chem Lett. 2014 Feb 15;24(4):1080-4. [4]. Mengli Gu, et al. Rabeprazole Exhibits Antiproliferative Effects on Human Gastric Cancer Cell Lines. Oncol Lett. 2014 Oct;8(4):1739-1744.

C.I. Pigment yellow 180