| Bioactivity | RXR antagonist 6 (Compound 33) is a highly selective RXR agonist, with EC50s of 9 nM, 18 nM, and 11 nM for RXRα, RXRβ, and RXRγ, respectively. RXR antagonist 6 binds to RXR with high affinity (Kd = 0.03 μM)[1]. |
| Name | RXR antagonist 6 |
| Formula | C18H20ClN3O3 |
| Molar Mass | 361.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lewandowski M, et al. Structure-Guided Design of a Highly Potent Partial RXR Agonist with Superior Physicochemical Properties. J Med Chem. 2024 Jan 18. |