| Bioactivity | RXFP2 agonist 2 is a selective and allosteric RXFP2 agonist with an EC50 value of 0.38 µM. RXFP2 agonist 2 induces osteoblast mineralization. RXFP2 agonist 2 increases bone formation in female mice. RXFP2 agonist 2 has the potential for the research of osteoporosis[1]. |
| Target | EC50: 0.38 µM (RXFP2) |
| Invitro | RXFP2 agonist 2 (Compound 6641) (1, 3, 5 µM; 14 天) 在 3 和 5 µM 诱导成骨细胞矿化，对 HCO 细胞无细胞毒性[1]。 Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | RXFP2 agonist 2 (10 mg/kg; p.o.; 每周 3 次，8 周) 促进雌性小鼠骨形成[1]。 Animal Model: |
| Name | RXFP2 agonist 2 |
| Formula | C29H19F9IN3O5 |
| Molar Mass | 787.37 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Esteban-Lopez M, et al. Discovery of small molecule agonists of the Relaxin Family Peptide Receptor 2. Commun Biol. 2022 Nov 4;5(1):1183. |