| Bioactivity | RX 67668 is a potent cholinesterase inhibitor with an IC50 of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue[1][2]. |
| Target | IC50: 5 μM (acetylcholinesterase) and 5 μM (butyrylcholinesterase) |
| In Vivo | RX 67668 (1-4 mg/kg; i.p.) reduces by half the dose of methacholine necessary to produce red tears, whilst RX 67668 (7-2 mg/kg s.c.) is necessary to reduce the pupil diameter of the mouse to 50% of the control value[1]. Rat anterior tibialis preparation of the cat tibialis preparation demonstrates that RX 67668 (0.3-1.0 mg/kg; i.v.) is effective in reversing tubocurarine-induced muscle blockade[1]. |
| Name | RX 67668 |
| CAS | 40709-76-0 |
| Formula | C16H24ClN |
| Molar Mass | 265.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Doxey JC, et al. Some pharmacological properties of RX 67668--a new anticholinesterase. Br J Pharmacol. 1972 Nov;46(3):568P-569P. [2]. Metcalf G, wt al. Evaluation of RX 72601 as an anti-curare agent. Br J Anaesth. 1975 Apr;47(4):451-6. |