| Bioactivity | RX-37 is a selective BET inhibitor. RX-37 binds to BET bromodomain proteins (BRD2, BRD3, and BRD4) with Ki values of 3.2-24.7 nM. RX-37 can be used for research of cancers[1]. |
| Target | Ki: 11.1 nM, 11.7 nM, 7.3 nM, 3.2 nM, 24.7 nM, 12.2 nM (BRD2, BRD3, and BRD4 BD1 and BD2). |
| Name | RX-37 |
| CAS | 1627715-60-9 |
| Formula | C24H23N5O2 |
| Molar Mass | 413.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ran X, et al. Structure-Based Design of γ-Carboline Analogues as Potent and Specific BET Bromodomain Inhibitors. J Med Chem. 2015 Jun 25;58(12):4927-39. |