| Bioactivity | RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction with an IC50 of 5.0 μM (HL60 cells). RWJ 50271 inhibits LFA-1/ICAM-1-mediated cell adhesion[1]. | ||||||||||||
| Target | IC50: 5.0 μM (LFA-1/ICAM-1, HL60 cells) | ||||||||||||
| Invitro | RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1[1].RWJ 50271 inhibits both human and murine NK activity (IC50=5.0 μM) in an LFA-1/ICAM-1-dependent natural killer [NK] cytotoxicity assay[1].RWJ 50271 does not inhibit Mac-1/ICAM-1, E-selectidsialyl Lewis X or VLA-4/VCAM-1-mediated cell adhesion up to 20 μM concentrations[1].RWJ 50271 does not alter the LFA-1 expression levels on HL60 cells[1].RWJ 50271 inhibits adhesion of peripheral blood lymphocytes to plastic immobilized SICAM-1[1].RWJ 50271 does not exhibit any toxic activity up to 100 μM concentrations[1]. | ||||||||||||
| In Vivo | RWJ 50271 (50 mg/kg; p.o.) is effective in animal model of inflammation[1]. Animal Model: | ||||||||||||
| Name | RWJ 50271 | ||||||||||||
| CAS | 162112-37-0 | ||||||||||||
| Formula | C18H17F3N4O2S | ||||||||||||
| Molar Mass | 410.41 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Sanfilippo PJ, et al. Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J Med Chem. 1995 Mar 31;38(7):1057-9. |
RWJ 50271
CAS: 162112-37-0 F: C18H17F3N4O2S W: 410.41
RWJ 50271 is an selective and orally active inhibitor of lymphocyte function-associated antigen-1/intercellular adhesion
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