| Bioactivity | RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhibits addictive agent induced locomotor activity and self-administration in Lewis rats. RTI 336 exhibits inhibitory effects depending on inherent NAc DAT levels[1]. |
| In Vivo | RTI 336（3 mg/kg；皮下注射；30 分钟预处理）显著减少 Lewis 大鼠对成瘾剂的输注次数[1]。RTI 336（3 毫克/千克；腹腔注射；30 分钟预处理）降低 Lewis 大鼠中由成瘾剂诱导的反应率（杠杆按压/秒）[1]。 |
| Name | RTI 336 |
| CAS | 204069-50-1 |
| Formula | C24H26Cl2N2O |
| Molar Mass | 429.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Haile CN, et al. Cocaine self-administration and locomotor activity are altered in Lewis and F344 inbred rats by RTI 336, a 3-phenyltropane analog that binds to the dopamine transporter. Brain Res. 2005 Sep 7;1055(1-2):186-95. |
RTI 336
CAS: 204069-50-1 F: C24H26Cl2N2O W: 429.38
RTI 336 is a phenyltropane analog, as well as a potent and selective dopamine transporter (DAT) inhibitor. RTI 336 inhib
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