| Bioactivity | RSV604 (A-60444) is an inhibitor of respiratory syncytial virus (RSV) replication. RSV604 targets the nucleocapsid protein, with a Kd of 1.6 μM. RSV604 displays submicromolar activity against numerous clinical isolates of both the A and B subtypes of RSV (average EC50s=0.8 μM)[1][2]. | ||||||||||||
| Target | Kd: 1.6 μM (nucleocapsid protein) | ||||||||||||
| Invitro | RSV604 (5 days) inhibits the growth of four laboratory strains of RSV (RSS, Long, A2 and B), with EC50s ranging from 0.5 to 0.9 μM in plaque reduction assay[1].RSV604 (6 days) inhibits RSV-induced HEp-2 cell death, with an EC50 of 0.86 μM[1].RSV604 (3 days) reduces viral antigen synthesis in RSV-infected HEp-2 cells, with an EC50 of 1.7 μM[1].RSV604 (1-20 μM; 7 days) dose-dependently inhibits RSV infection in human airway epithelial (HAE) cells, with no gross cytotoxicity, leakage of basolateral fluid to the apical surface, or alteration of cilium beat frequency[1]. | ||||||||||||
| Name | RSV604 | ||||||||||||
| CAS | 676128-63-5 | ||||||||||||
| Formula | C22H17FN4O2 | ||||||||||||
| Molar Mass | 388.39 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Chapman J, et al. RSV604, a novel inhibitor of respiratory syncytial virus replication. Antimicrob Agents Chemother. 2007 Sep;51(9):3346-53. [2]. Challa S, et al. Mechanism of action for respiratory syncytial virus inhibitor RSV604. Antimicrob Agents Chemother. 2015 Feb;59(2):1080-7. |