RSV L-protein-IN-3_product_DataBase

Bioactivity	RSV L-protein-IN-3 is a wild-type RSV polymerase inhibitor with an IC50 value of 10.4 μM and an EC50 value of 2.1 μM (against RSV). RSV L-protein-IN-3 has lesser cytotoxicity than the clinical agent, Ribavirin (HY-B0434)[1].
Target	IC50: 10.4 μM (RSV)
Invitro	RSV L-protein-IN-3(compound B) 在 HEp-2 cell 细胞中具有一定的细胞毒性，CC50 值为 16μM[1]。RSV L-protein-IN-3 在 HEp-2 cell 细胞中抑制 RSV 病毒转录，EC50 值为 2.1μM[1]。 Antiviral Assay Cell Line:
Name	RSV L-protein-IN-3
CAS	868860-35-9
Formula	C31H34N4O4
Molar Mass	526.63
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Michel Liuzzi, et al. Inhibitors of respiratory syncytial virus replication target cotranscriptional mRNA guanylylation by viral RNA-dependent RNA polymerase. J Virol. 2005, 79(20). [2]. Michael T. Rudd, et al. Discovery of MK-8768, a Potent and Selective mGluR2 Negative Allosteric Modulator. ACS Med. Chem. Lett.. 2023，14，8. [3]. Sean M Smith, et al. The novel phosphodiesterase 10A inhibitor THPP-1 has antipsychotic-like effects in rat and improves cognition in rat and rhesus monkey.Neuropharmacology, 2013 Jan;64:215-23.

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