| Bioactivity | RSM3 TFA, a stapled peptide, is a METTL3-METTL14 inhibitor with an Kd of 3.10 μM. RSM3 TFA inhibits tumor growth while induces cell apoptosis. RSM3 TFA can be used for study of cancer[1]. |
| Sequence | Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Cys-Met-Glu-Leu-Gly-Arg-Glu-Cys-Leu-Asn-Leu (Stapled between two Cys via bhp) |
| Shortening | RRRRRRRRRCMELGRECLNLW (Stapled between two Cys via bhp) |
| Formula | C116H208N54O26S3.xC2HF3O2 |
| Molar Mass | 2871.43 (free base) |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li Z, et al. A Stapled Peptide Inhibitor Targeting the Binding Interface of N6-Adenosine-Methyltransferase Subunits METTL3 and METTL14 for Cancer Therapy. Angew Chem Int Ed Engl. Published online April 12, 2024. |
RSM3 TFA
CAS: F: C116H208N54O26S3.xC2HF3O2 W: 2871.43 (free base)
RSM3 TFA, a stapled peptide, is a METTL3-METTL14 inhibitor with an Kd of 3.10 μM. RSM3 TFA inhibits tumor growth while
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