| Bioactivity | RSK2-IN-4 (Compound 10) is a RSK2 inhibitor, with an inhibition rate of 13.73% on RSK2 activity at 10 μM. RSK2-IN-4 binds to the ATP-binding site of RSK2 in the NTKD (N-terminal kinase domain), with the electron-donating group at the 4-position of the phenyl ring being the key determinant for its inhibitory activity [1]. |
| CAS | 62001-32-5 |
| Formula | C13H11ClN4 |
| Molar Mass | 258.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yuan J, et al. Triazole and benzotriazole derivatives as novel inhibitors for p90 ribosomal S6 protein kinase 2: synthesis, molecular docking and SAR analysis[J]. Chinese Journal of Chemistry, 2013, 31(9): 1192-1198. |