| Bioactivity | RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound. | ||||||||||||
| Invitro | RP-54745 diminishes LPS-induced interleukin-1 (IL-1) production by murine peritoneal macrophages[1]. | ||||||||||||
| In Vivo | RP-54745 (5 mg/kg) is effective at moderating oral doses in different mouse models of induced arthritis and in the MRL/lpr mice, genetically predisposed to develop an autoimmune pathology including arthritic disorders. The clinical status of the MRL mice, and several of their disturbed biochemical and immunological parameters, improved after a 3-month treatment with RP-54745[2]. | ||||||||||||
| Name | RP-54745 | ||||||||||||
| CAS | 135330-08-4 | ||||||||||||
| Formula | C13H12ClNOS2 | ||||||||||||
| Molar Mass | 297.82 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Folliard F, et al. RP 54745, a potential antirheumatic compound. I. Inhibitor of macrophage stimulation and interleukin-1 production. Agents Actions. 1992 May;36(1-2):119-26. [2]. Folliard F, et al. RP 54745, a potential antirheumatic compound. II. In vivo properties in different animal models. Agents Actions. 1992 May;36(1-2):127-35. |
RP-54745
CAS: 135330-08-4 F: C13H12ClNOS2 W: 297.82
RP-54745 is an inhibitor of macrophage stimulation and interleukin-1 production, and a potential antirheumatic compound.
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.