RP-001 hydrochloride

CAS: 1781880-34-9 F: C24H25ClN4O4 W: 468.93

RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochlorid

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Bioactivity	RP-001 hydrochloride is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 hydrochloride induces internalization and polyubiquitination of S1P1. RP-001 hydrochloride has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].
Invitro	RP-001 hydrochloride elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 hydrochloride induces acute lymphopenia with rapid recovery to untreated levels[1].
In Vivo	RP-001 hydrochloride causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1].
Name	RP-001 hydrochloride
CAS	1781880-34-9
Formula	C24H25ClN4O4
Molar Mass	468.93
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Cahalan SM, et al. Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat Chem Biol. 2011 May;7(5):254-6.

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