| Bioactivity | ROS inducer 4 (compound TE3) is a mitochondrial inhibitor. ROS inducer 4 causes a series of mitochondria-related physiological changes in tumors, such as mitochondrial fragmentation, explosive generation and accumulation of ROS, decreased mitochondrial membrane potential, decreased ATP content, and activation of ROS-mediated apoptotic signaling in mitochondria[1]. |
| Invitro | ROS inducer 4 (compound TE3) 对 HeLa、A549 和 HCT-15 细胞表现出抗癌活性，IC50 值分别为 4.83、3.49 和 8.74 μM[1]。ROS inducer 4 (8 µM) 通过诱导 ROS 破坏 HeLa 细胞中的线粒体功能[1]。ROS inducer 4 (1-8 µM) 以剂量依赖性方式诱导 HeLa 细胞中的细胞凋亡[1]。与母体分子Ergosterol peroxide (HY-N3845)相比，ROS inducer 4 表现出大大增强的抗癌活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ROS inducer 4 相关抗体: |
| In Vivo | ROS inducer 4 (compound TE3) 在C57BL/6雌性小鼠中的LD50为70mg/kg，95%置信区间为59.29-97.9mg/kg[1]。ROS inducer 4 (1-2mg/kg) 比 Cisplatin (HY-17394) 具有更好的抗宫颈癌活性和安全性，并能激活小鼠的免疫反应[1]。ROS inducer 4 具有中等毒性，ROS inducer 4 在有效剂量 (1 mg/kg) 下无明显毒性作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C49H62BrO4P |
| Molar Mass | 825.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu P, et al. Mitochondrial targeted modification and anticancer mechanism of natural product ergosterol peroxide. Bioorg Chem. 2024 Jul 31;151:107688. |