| Bioactivity | ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor C2 (RORC2), inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5[1]. |
| Target | pIC 50: 7.5 (human primary TH 17 cells) |
| Name | ROR agonist-1 |
| CAS | 2361528-74-5 |
| Formula | C21H20F6N2O5S |
| Molar Mass | 526.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. von Berg S, et al. Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2. ACS Med Chem Lett. 2019 May 29;10(6):972-977. |
ROR agonist-1
CAS: 2361528-74-5 F: C21H20F6N2O5S W: 526.45
ROR agonist-1 is a potent and orally bioavailable inverse agonist of the retinoic acid receptor-related orphan receptor
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