ROCK2-IN-7_product_DataBase

Bioactivity	ROCK2-IN-7 is a kinase inhibitor targeting to ROCK2. ROCK2-IN-7 inhibits ROCK2/pSTAT3 Signaling. ROCK2-IN-7 suppresses systemic immunity activation and attenuates inflammation in psoriasis model[1].
Invitro	ROCK2-IN-7 (2-5 μM, 24 小时) 在 HaCaT 细胞中抑制 ROCK2/pSTAT3 信号通路[1]。 0 --> ROCK2-IN-7 相关抗体: Western Blot Analysis Cell Line:
In Vivo	ROCK2-IN-7（20-80 mg/kg，口服，连续 7 天）降低与 IL-23/Th17 轴相关的关键白细胞介素和参与角质形成细胞增殖的重要因子[1]。ROCK2-IN-79（20-80 mg/kg，口服，连续 7 天）抑制全身免疫激活，减轻炎症[1]。 Animal Model:
Name	ROCK2-IN-7
CAS	3000541-95-4
Formula	C26H28FN5O
Molar Mass	445.53
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Huang, Yun, et al. "Design, Synthesis, and Biological Evaluation of an Orally Bioavailable, Potent, and Selective ROCK2 Inhibitor for Psoriasis Treatment." Journal of Medicinal Chemistry (2023)

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