| Bioactivity | RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation[1]. |
| Name | RO6889678 |
| CAS | 1578153-27-1 |
| Formula | C21H20ClFN4O5S |
| Molar Mass | 494.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nicole A Kratochwil, et al. Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor. J Pharmacol Exp Ther. 2018 May;365(2):237-248. |
RO6889678
CAS: 1578153-27-1 F: C21H20ClFN4O5S W: 494.92
RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and exc
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