| Bioactivity | RO5353 is an orally active inhibitor for p53-MDM2 with an IC50 of 7 nM for MDM2. RO5353 inhibits the proliferation of wild-type p53 cancer cells with an average IC50 of 7 nM. RO5353 exhibits antitumor efficacy and good pharmacokinetic characteristics in mice[1]. |
| CAS | 1360821-61-9 |
| Formula | C29H29Cl2FN4O4S |
| Molar Mass | 619.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang Z, et al., Discovery of Potent and Orally Active p53-MDM2 Inhibitors RO5353 and RO2468 for Potential Clinical Development. ACS Med Chem Lett. 2013 Dec 29;5(2):124-7. |
RO5353
CAS: 1360821-61-9 F: C29H29Cl2FN4O4S W: 619.53
RO5353 is an orally active inhibitor forp53-MDM2 with an IC50 of 7 nM for MDM2. RO5353 inhibits the proliferation of wil
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