| Bioactivity | RO-76 is a mu opioid receptor (μOR) selective partial agonist. RO-76 binds to μOR-G-protein complex with an EC50 value of 454 nM. RO-76 reduces β-Arrestin-1/2 recruitment. RO-76 shows antinociception activity[1]. |
| Invitro | RO-76 通过水分子与钠位残基相互作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> RO-76 相关抗体: |
| In Vivo | RO-76 (1, 3, 10, 30 mg/kg; s.c.) 在小鼠中表现出剂量依赖性镇痛作用，ED50 值为 10.18 mg/kg[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C24H32N2O2 |
| Molar Mass | 380.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Rohini S. Ople, et al. Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at μOR. ACS Cent. Sci. 2024. |