| Bioactivity | RO-275 (compound 29) is a potent, selective and orally active HCN1 inhibitor with IC50 values of 0.046, 14.3, 4.6, 13.9 µM for HCN1, HCN2, HCN3, HCN4, respectively. RO-275 rescues decremented working memory. RO-275 has the potential for the research of cognitive dysfunction in brain disorder[1][2]. |
| Target | IC50: 0.046 µM (HCN1); 14.3 µM (HCN2); 4.6 µM (HCN3); 13.9 µM (HCN4) |
| In Vivo | RO-275 (3, 10, 30 mg/kg; i.p.) 可挽救大鼠工作记忆减退[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 2648837-04-9 |
| Formula | C18H14ClN5O |
| Molar Mass | 351.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bjoern Bartels, et al. Alkynyl-(heteroaryl)-carboxamide hcn1 inhibitors. WO2021110574A1. [2]. Harde E, et al. Selective and brain-penetrant HCN1 inhibitors reveal links between synaptic integration, cortical function, and working memory. Cell Chem Biol. 2024 Mar 21;31(3):577-592.e23. |