| Bioactivity | RNase III is a double-stranded RNA (dsRNA)-specific endonuclease from Escherichia coli expressing the RNase III gene. RNase III proteins are Mg2+-dependent endonucleases with a nine-residue signature motif, the RNase III domain. RNase III can cleave dsRNA into 12-15 bp small fragments of interfering RNA (siRNA), which are more suitable for RNA interference experiments in mammalian cells[1][2]. |
| Name | RNase III |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Court DL, et al. RNase III: Genetics and function; structure and mechanism. Annu Rev Genet. 2013;47:405-31. [2]. Maurin T, et al. RNase III-independent microRNA biogenesis in mammalian cells. RNA. 2012 Dec;18(12):2166-73. |