| Bioactivity | RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibits tRNA maturation with an IC50 of 175 μM. RNPA1000 displays broad-spectrum antimicrobial activities and inhibits staphylococcal and all Gram-positive bacterial pathogens activity[1][2][3]. | ||||||||||||
| Invitro | RNPA1000 displays antimicrobial activity toward Gram-positive bacteria and little or no toxicity toward human cells[2]. RNPA1000 limits S. aureus mRNA turnover and growth. RNPA1000 also limits growth of other important Gram-positive bacterial pathogens, exhibits antimicrobial efficacy against biofilm associated S. aureus and protects against the S. aureus pathogenesis in an animal model of infection[3].RNPA1000 (IC50= 100-125 µM), does not affect the activity of the commercially available E. coli RNase HI, RNase A, RNase I or in-house purified S. aureus RNase J1 at any concentration tested (0-750 µM), but does mildly inhibit E. coli RNase III activity (IC50= 500-750 µM)[3]. | ||||||||||||
| Name | RNPA1000 | ||||||||||||
| CAS | 359600-10-5 | ||||||||||||
| Formula | C23H18BrN3O3 | ||||||||||||
| Molar Mass | 464.31 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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RNPA1000
CAS: 359600-10-5 F: C23H18BrN3O3 W: 464.31
RNPA1000, an antibiotic, is a potent RnpA inhibitor and inhibits RnpA-mediated cellular RNA degradation. RNPA1000 inhibi
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