| Bioactivity | RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 values are 0.77 μM, 4.0 μM and 4.1 μM for hTRPV4, mTRPV4 and rTRPV4 respectively. RN-1747 also antagonizes TRPM8, with an IC50 of 4 μM[1]. | ||||||||||||
| Target | EC50: 0.77 μM (hTRPV4), 4.0 μM (mTRPV4), 4.1 μM (rTRPV4) . | ||||||||||||
| Name | RN-1747 | ||||||||||||
| CAS | 1024448-59-6 | ||||||||||||
| Formula | C17H18ClN3O4S | ||||||||||||
| Molar Mass | 395.86 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Vincent F, et al. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun. 2009 Nov 20;389(3):490-4. |
RN-1747
CAS: 1024448-59-6 F: C17H18ClN3O4S W: 395.86
RN-1747 is a selective transient receptor potential cation channel subfamily V member 4 (TRPV4) agonist, with EC50 value
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