| Bioactivity | RMC-4998 is a molecular glue compound with good antitumor activity. RMC-4998 is able to form a ternary complex with CYPA and an activated KRAS G12C mutant. Furthermore, CYPA binding to KRAS G12C blocks the interaction between activated KRAS mutants and downstream effector proteins, thereby inhibiting signaling that promotes cell proliferation[1]. |
| Name | RMC-4998 |
| CAS | 2642037-07-6 |
| Formula | C57H74N8O7 |
| Molar Mass | 983.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Christopher J Schulze, et al. Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS. Science. 2023 Aug 18;381(6659):794-799. |
RMC-4998
CAS: 2642037-07-6 F: C57H74N8O7 W: 983.25
RMC-4998 is a molecular glue compound with good antitumor activity. RMC-4998 is able to form a ternary complex with CYPA
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.