| Bioactivity | RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50 value of 0.18 µM but not other human sirtuin members including SIRT1 and SIRT3 at 100 µM. RK-9123016 increases the acetylation level of eukaryotic translation initiation factor 5A (eIF5A), a physiological substrate of SIRT2, and reduces cell viability of human breast cancer cells accompanied with a decrease in c-Myc expression[1]. |
| Name | RK-9123016 |
| CAS | 955900-27-3 |
| Formula | C16H18N6O3S |
| Molar Mass | 374.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Asad Ali Shah, et al. Identification of a Selective SIRT2 Inhibitor and Its Anti-breast Cancer Activity. Biol Pharm Bull. 2016;39(10):1739-1742. |
RK-9123016
CAS: 955900-27-3 F: C16H18N6O3S W: 374.42
RK-9123016 is a potent inhibitor of SIRT2. RK-9123016 inhibits the enzymatic activity of SIRT2 with an IC50 value of 0.
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