| Bioactivity | RIPK3-IN-3 (compound 20) is a selective inhibitor of RIP kinase RIPK3 (IC50=10 nM). RIPK3 mediates the phosphorylation of Mixed Lineage Kinase (MLKL) and causes necroptosis, while RIPK3-IN-3 inhibits p-MLKL oligomerization and thereby inhibits necroptosis. RIPK3-IN-3 also downregulates CXCL5 secretion and inhibits AsPC-1 cell migration and invasion[1]. |
| Target | IC50: 10 nM (RIPK3) |
| Invitro | 0 --> RIPK3-IN-3 相关抗体: Western Blot Analysis [1] Cell Line: |
| In Vivo | Animal Model: |
| Name | RIPK3-IN-3 |
| Formula | C16H11N5S |
| Molar Mass | 305.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Namkyoung Kim, et al. Identification of Pyrido[3,4-d]pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors. Eur J Med Chem. 2023, 259, 115635. [2]. Kim N, et al. Identification of Pyrido [3, 4-d] pyrimidine derivatives as RIPK3-Mediated necroptosis inhibitors[J]. European Journal of Medicinal Chemistry, 2023, 259: 115635... |