| Bioactivity | RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kinase and binds to a DLG-out inactive form of RIP1 with an IC50s of 16 nM and 10 nM for RIP1 and ADP-Glo kinase[1]. | ||||||||||||
| Target | IC50: 16 nM (RIP1) and 10 nM (ADP-Glo) | ||||||||||||
| Name | RIPK1-IN-4 | ||||||||||||
| CAS | 1481641-08-0 | ||||||||||||
| Formula | C23H23N5O2 | ||||||||||||
| Molar Mass | 401.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Harris PA, et al. Discovery of Small Molecule RIP1 Kinase Inhibitors for the Treatment of Pathologies Associated with Necroptosis. ACS Med Chem Lett. 2013 Nov 4;4(12):1238-43. |
RIPK1-IN-4
CAS: 1481641-08-0 F: C23H23N5O2 W: 401.46
RIPK1-IN-4 (compound 8) is a potent and selective type II kinase inhibitor of receptor interacting protein 1 (RIP1) kina
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