| Bioactivity | RIPK1-IN-19 (compound 10b) is a selective RIPK1 inhibitor (IC50=15 nM). RIPK1-IN-19 displays potent protective activity in TNFα-induced systemic inflammatory response syndrome (SIRS) model and Imiquimod (IMQ)-induced psoriasis model. RIPK1-IN-19 can be used in research on inflammation and immune system diseases[1]. |
| Name | RIPK1-IN-19 |
| CAS | 2763831-43-0 |
| Formula | C28H25FN6O2 |
| Molar Mass | 496.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang L, et al. From Hit to Lead: Structure-Based Optimization of Novel Selective Inhibitors of Receptor-Interacting Protein Kinase 1 (RIPK1) for the Treatment of Inflammatory Diseases. J Med Chem. 2024 Jan 11;67(1):754-773. |
RIPK1-IN-19
CAS: 2763831-43-0 F: C28H25FN6O2 W: 496.54
RIPK1-IN-19 (compound 10b) is a selective RIPK1 inhibitor (IC50=15 nM). RIPK1-IN-19 displays potent protective activity
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This product is for research use only, not for human use. We do not sell to patients.