RIPK1-IN-12_product_DataBase

CAS: 2173556-92-6 F: C24H26N4O3S W: 450.55

RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC50 value

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	RIPK1-IN-12 is a potent RIPK1 inhibitor. RIPK1-IN-12 inhibits necroptosis in both human and mouse cells, with EC50 values of 1.6 and 2.9 nM, respectively[1].
Target	RIPK1
Invitro	RIPK1-IN-12 (Compound 58; 24 hours) demonstrates potent anti-necroptotic activity (EC50=1.6 nM in HT-29 cells and EC50= 2.9 nM in L929 cells)[1].
Name	RIPK1-IN-12
CAS	2173556-92-6
Formula	C24H26N4O3S
Molar Mass	450.55
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li Z, et al. Design, synthesis, and evaluation of potent RIPK1 inhibitors with in vivo anti-inflammatory activity. Eur J Med Chem. 2022, 228:114036.

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