RIP1 kinase inhibitor 9_product_DataBase

Bioactivity	RIP1 kinase inhibitor 9 (compound SY-1) is a selective RIP kinase inhibitor. RIP1 kinase inhibitor 9 effectively suppresses the central inflammatory response induced by epilepsy. RIP1 kinase inhibitor 9 inhibits TSZ-induced necroptosis in HT-29 cells with an EC50 of 7.04 nM[1].
Invitro	RIP1 kinase inhibitor 9 (10 nM, 4 h) 有效阻止 RIP1 和 RIP3 的磷酸化，阻碍坏死体的形成[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> RIP1 kinase inhibitor 9 相关抗体:
In Vivo	RIP1 kinase inhibitor 9 (5 mg/kg，口服；每天 1 次，连续 7 天) 抑制癫痫小鼠模型的炎症[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Formula	C25H21N3O3
Molar Mass	411.45
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jiang R, et al. Scaffold hopping derived novel benzoxazepinone receptor-interacting protein kinase 1 (RIP1) inhibitors as anti-necroptosis agents: Anti-inflammatory effect in systemic inflammatory response syndrome (SIRS) and epilepsy. Eur J Med Chem. 2024 Mar 9;269:116304.

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