| Bioactivity | RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS)-induced β cell dysfunction and death, and inhibits proapoptotic gene expression. RH01386 restores ERS-impaired glucose-stimulated insulin secretion responses. RH01386 has the potential for type 2 diabetes treatment[1]. |
| Invitro | RH01386 (270 nM-70 μM; 72 hours) is confirmed to increase ATP levels in βTC6 cells treated with (tunicamycin) Tm, exhibits a EC50 value of 1.894 μM[1].RH01386 (270 nM-70 μM; 72 hours) dose-dependently inhibits (tunicamycin) Tm-induced cell death, and inhibits the activity of caspase-3, a downstream effector of the apoptotic pathway in βTC6 cells[1]. Cell Viability Assay[1] Cell Line: |
| Name | RH01386 |
| CAS | 301177-36-6 |
| Formula | C18H15F3N4O3S |
| Molar Mass | 424.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
RH01386
CAS: 301177-36-6 F: C18H15F3N4O3S W: 424.40
RH01386 is a small molecule that can prevent endoplasmic reticulum stress (ERS)-induced β cell dysfunction and death, a
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