| Bioactivity | RGH-560 (compound 53) shows highly advanced α7 nAChR positive modulator properties and favorable physicochemical features. RGH-560 has robust procognitive in vivo potential. RGH-560 can be used to study Scopolamine (HY-N0296) -induced amnesia in mice[1]. |
| In Vivo | RGH-560 (compound 53) (1 mg/kg, 3 mg/kg, 10 mg/kg;腹腔注射) 对东莨菪碱 (HY-N0296) 引起的小鼠遗忘症具有显著的认知增强作用。RGH-560 是一种中等清除率化合物。RGH-560剂量高达 30 mg/kg 时，对小鼠无毒性[1]。 Animal Model: |
| Name | RGH-560 |
| CAS | 2408799-43-7 |
| Formula | C22H20FN3O3 |
| Molar Mass | 393.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ledneczki I, et al. Optimization of Novel α7 Nicotinic Acetylcholine Receptor Positive Allosteric Modulators and the Discovery of a Preclinical Development Candidate Molecule (RGH-560). Journal of Medicinal Chemistry. 2023 Nov. |