| Bioactivity | RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1 binding with extracellular matrice (ECM). RGD peptide (GRGDNP) promotes apoptosis through activation of conformation changes that enhance pro-caspase-3 activation and autoprocessing. RGD peptide (GRGDNP) plays an important role in cell adhesion, migration, growth, and differentiation[1][2][3]. |
| Invitro | RGD peptide (GRGDNP) (50 μM ; preincubation for 3 hours before stretch) abolishes stretch-induced IKK activation and IL-6 mRNA expression. It shows little effect on the IKK activity and IL-6 mRNA expression in unstretched HUVECs[2]. RGD peptide (GRGDNP) (300 μg/mL; for 6 hours) completely reverses enhanced FN1 expression in oxygen glucose deprivation(OGD) treated primary hippocampal neurons, HT22 cell lines and in its sEVs[3]. |
| Name | RGD peptide (GRGDNP) |
| CAS | 114681-65-1 |
| Sequence | Gly-Arg-Gly-Asp-Asn-Pro |
| Shortening | GRGDNP |
| Formula | C23H38N10O10 |
| Molar Mass | 614.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
RGD peptide (GRGDNP)
CAS: 114681-65-1 F: C23H38N10O10 W: 614.61
RGD peptide (GRGDNP) is an inhibitor of integrin-ligand interactions. RGD peptide (GRGDNP) competitively inhibits α5β1
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