| Bioactivity | REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC50 of 78 μM, which directly binds to REV7 in nuclear magnetic resonance analyses, and inhibits the reactivation of a reporter plasmid containing an interstrand crosslink (ICL) in between the promoter and reporter regions[1]. | ||||||||||||
| Target | IC50: 78 μM (REV7/REV3L interaction) | ||||||||||||
| Name | REV7/REV3L-IN-1 | ||||||||||||
| CAS | 1979192-13-6 | ||||||||||||
| Formula | C19H21N3O3S | ||||||||||||
| Molar Mass | 371.45 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Actis ML, et al. Identification of the first small-molecule inhibitor of the REV7 DNA repair protein interaction. Bioorg Med Chem. 2016 Sep 15;24(18):4339-4346. |
REV7/REV3L-IN-1
CAS: 1979192-13-6 F: C19H21N3O3S W: 371.45
REV7/REV3L-IN-1 is a REV7/REV3L interaction inhibitor with an IC50 of 78 μM, which directly binds to REV7 in nuclear ma
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