| Bioactivity | RET-IN-27 (compound 20p) is a potent inhibitor of RET, with IC50s of 3.6 nM, 0.1 nM, 2.1 nM, 0.3 nM for RETWT, RETV804L, RETV804M, RETM918T, respectively. RET-IN-27 plays an important role in cancer research[1]. |
| Formula | C31H28N8O |
| Molar Mass | 528.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Junbo Wu, et al. Discovery of 7-(1-methyl-1H-pyrazol-4-yl)-1,6-naphthyridine derivatives as potent inhibitors of rearranged during transfection (RET) and RET solvent-front mutants for overcoming selpercatinib resistance. Eur J Med Chem. 2024 Sep 19:279:116891. |