| Bioactivity | RET-IN-20 is a potent RET inhibitor with an IC50 value of 13.7 nM. RET-IN-20 decreases the expression of p-Ret, p-Shc protein. RET-IN-20 induces apoptosis. RET-IN-20 shows antiproliferative and anti-tumor activity[1]. |
| Invitro | RET-IN-20 (compound 8q) (0, 1.2, 3.7, 11.1, 33.3, 100 nM; 4 h) 以剂量依赖性方式降低 p-Ret、p-Shc 蛋白的表达[1]。RET-IN-20 (0, 33.3, 100, 300 nM; 48 h) 以剂量依赖的方式诱导细胞凋亡[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | RET-IN-20 |
| Formula | C32H33FN6O4 |
| Molar Mass | 584.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |