| Bioactivity | RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM). RECQL5-IN-1 inhibits RECQL5-WT cells and RECQL5-KO2 cells with IC50s of 4.8 μM and 19.6 μM, respectively. RECQL5-IN-1 can be used for the research of breast cancer[1]. | ||||||||||||
| Name | RECQL5-IN-1 | ||||||||||||
| CAS | 2718170-45-5 | ||||||||||||
| Formula | C25H18F6N4O2S | ||||||||||||
| Molar Mass | 552.49 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Saikat Chakraborty, et al. Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitr o and in Vivo. J Med Chem. 2021 Feb 11;64(3):1524-1544. |
RECQL5-IN-1
CAS: 2718170-45-5 F: C25H18F6N4O2S W: 552.49
RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.