| Bioactivity | RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4SPA IC50 and RBP4–TTR FRET IC50 values are 0.23±0.11 and 0.13±0.12 μM in the radioligand binding assay and FRET assay, respectively[1]. |
| Invitro | Retinol-Binding Protein 4 (RBP4) is a physiological carrier of retinol (vitamin A) in blood, delivering retinol from the liver to peripheral tissues.RBP4 ligand-1 has the ability to disrupt the RBP4–TTR protein–protein interaction (hRPB4–TTR). The RBP4–TTR FRET IC50 is 0.13±0.12 μM in FRET assay[1]. |
| In Vivo | RBP4配体 |
| Name | RBP4 ligand-1 |
| CAS | 260553-24-0 |
| Formula | C18H18ClF3N4O2 |
| Molar Mass | 414.81 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yingcai Wang, et al. Structure-assisted discovery of the first non-retinoid ligands for Retinol-Binding Protein 4. Bioorg Med Chem Lett. 2014 Jul 1;24(13):2885-91. |
RBP4 ligand-1
CAS: 260553-24-0 F: C18H18ClF3N4O2 W: 414.81
RBP4 ligand-1 is a non-retinoid ligands for (RBP4) retinol-binding protein 4. The hRBP4SPA IC50 and RBP4–TTR FRET IC50
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