| Bioactivity | RB-005 is a selective inhibitor of sphingosine kinase 1 (SK1) (IC50=3.6 µM), with weaker inhibition of another isoenzyme, SK2. The selective inhibition of RB-005 helps to distinguish the biological functions and roles of SK1 and SK2, which can be used in the study of inflammatory diseases and cancer[1]. |
| CAS | 1425049-20-2 |
| Formula | C21H35NO |
| Molar Mass | 317.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Baek D J, et al. Structure–activity relationships and molecular modeling of sphingosine kinase inhibitors[J]. Journal of medicinal chemistry, 2013, 56(22): 9310-9327. |