| Bioactivity | RAF265 is a potent and orally active RAF/VEGFR2 inhibitor. | ||||||||||||
| Invitro | The MTT assay reveals that in HT29 and MDAMB231 cells, RAF265 alone shows significant activity with IC20 values of 1 to 3 μM and IC50 values of 5 to 10 μM. In A549 and HCT116 cells, IC20 values are 1 μM for both, but RAF265 concentrations up to 10 μM do not reach IC50 values. However, in the presence of 1 nM RAD001, the IC50 for RAF265 is 5 μM in A549 cells and 10 μM in HCT116 cells[1]. | ||||||||||||
| Name | RAF265 | ||||||||||||
| CAS | 927880-90-8 | ||||||||||||
| Formula | C24H16F6N6O | ||||||||||||
| Molar Mass | 518.41 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|