| Bioactivity | R-BC154 acetate is a selective fluorescent α9β1 integrin antagonist. R-BC154 acetate acts as a useful high affinity, activation dependent integrin probe, which can be used to investigate α9β1 and α4β1 integrin binding activity[1]. |
| Invitro | R-BC154 acetate has 3 times greater affinities for α9β1 (Ki=12.7 nM) relative to α4β1 (Ki=38.0 nM) under Ca2+/Mg2+ conditions in human glioblastoma LN18 cell lines[1]. |
| In Vivo | R-BC154 acetate (10 mg/kg; i.v.) acts as an in vivo probe for bone marrow haemopoietic stem cells in mice[1]. Animal Model: |
| Name | R-BC154 acetate |
| Formula | C56H65N9O14S3 |
| Molar Mass | 1184.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Design, synthesis and binding properties of a fluorescent α9β1/α4β1 integrin antagonist and its application as an in vivo probe for bone marrow haemopoietic stem cells. Org Biomol Chem. 2014 Feb 14;12(6):965-78. |