| Bioactivity | R-87366 is a water-soluble human immunodeficiency virus (HIV) protease inhibitor. R-87366 has potent inhibitory for HIV protease with a Ki value of 11 nM. R-87366 can be used for the research of anti-human immunodeficiency virus (HIV)[1]. |
| Target | Ki: 11 nM (HIV protease).IC90: 0.5 μM (HIV-1IIIB acutely infected cells) |
| Invitro | R-87366 对人类免疫缺陷病毒蛋白酶具有强效抑制作用，Ki 值为 11 nM[1]。R-87366 对 HIV-1IIIB 急性感染细胞具有活性，IC90 值为 0.5 μM[1]。R-87366 具有中等水溶性[1]。R-87366 (0.25 μM; 0.5 μM) 对慢性感染的 Molt-4/HIV-1IIIB 细胞也有活性，并抑制 p55 蛋白水解加工成 p17[1]。 |
| Name | R-87366 |
| CAS | 144779-91-9 |
| Formula | C32H39N7O6 |
| Molar Mass | 617.70 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. T Komai, et al. In vitro and ex vivo anti-human immunodeficiency virus (HIV) activities of a new water-soluble HIV protease inhibitor, R-87366, containing (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid. Biol Pharm Bull. 1997 Feb;20(2):175-80. |