| Bioactivity | R-75317 is a specific platelet-activating factor (PAF) antagonist. R-75317 can prevent the decline in creatinine clearance (Ccr) in a rat model of glomerulonephritis induced by the injection of antibodies extracted from rabbits against rat glomerular basement membrane (GBM) antigens, delay the onset of proteinuria, and improve glomerular hypertrophy, mesangial matrix proliferation, and interstitial fibrosis. R-75317 may be useful in the study of glomerulonephritis[1]. |
| CAS | 115406-25-2 |
| Formula | C29H50N3O8PS |
| Molar Mass | 631.76 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Miyamoto M, et al. The effects of R-75,317 on antiglomerular basement membrane glomerulonephritis in rats. Lipids. 1991 Dec;26(12):1316-9. doi: 10.1007/BF02536556. |
R-75317
CAS: 115406-25-2 F: C29H50N3O8PS W: 631.76
R-75317 is a specific platelet-activating factor (PAF) antagonist. R-75317 can prevent the decline in creatinine clearan
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