Bioactivity | R-(–)-Flecainide is an orally active antiarrhythmic agent, which inhibits ventricular ectopic activity[1]. |
In Vivo | R-(–)-Flecainide 在小鼠模型中对氯仿诱导的纤颤 (9-20 mg/kg,口服,单剂量) 具有抑制作用,ED50 为 14.5 mg/kg,对 mongrel 狗模型中的 ouabain 诱导的心律失常有抑制作用 (1-3 mg/kg,静脉注射,单剂量),且不具备毒性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
CAS | 99495-90-6 |
Formula | C17H20F6N2O3 |
Molar Mass | 414.34 |
Transport | Room temperature in continental US; may vary elsewhere. |
Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Reference | [1]. Banitt EH, et al., Resolution of flecainide acetate, N-(2-piperidylmethyl)-2,5-bis(2,2,2-trifluoroethoxy)benzam ide acetate, and antiarrhythmic properties of the enantiomers. J Med Chem. 1986 Feb;29(2):299-302. |