| Bioactivity | R(+)-8-OH-DPAT ((R)-8-Hydroxy-2-dipropylaminotetralin) hydrobromide is a potent 5-HT1A agonist. R(+)-8-OH-DPAT potentiates SUL (HY-B1059)-induced dopamine (DA) release in the medial prefrontal cortex (mPFC)[1]. |
| In Vivo | R(+)-8-OH-DPAT hydrobromide (0.05 mg/kg; s.c.) 增强 SUL (HY-B1059) (10 和 25 mg/kg) 诱导的内侧前额叶皮质 (Mpfc) 多巴胺 (DA) 释放[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 78095-19-9 |
| Formula | C16H26BrNO |
| Molar Mass | 328.29 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ichikawa J, et al. R(+)-8-OH-DPAT, a serotonin(1A) receptor agonist, potentiated S(-)-sulpiride-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. J Pharmacol Exp Ther. 1999 Dec;291(3):1227-32. |
R(+)-8-OH-DPAT hydrobromide
CAS: 78095-19-9 F: C16H26BrNO W: 328.29
R(+)-8-OH-DPAT ((R)-8-Hydroxy-2-dipropylaminotetralin) hydrobromide is a potent 5-HT1A agonist. R(+)-8-OH-DPAT potentiat
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