Questiomycin A

CAS: 1916-59-2 F: C12H8N2O2 W: 212.20

Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer

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Bioactivity	Questiomycin A (Phx-3) is a GRP78 (cytoprotective endoplasmic reticulum chaperone) degrader and enhances the anticancer activity of Sorafenib. Questiomycin A is also an antimicrobial/antibiotic that can be obtained from the metabolite of Pseudomonas chlororaphis HT66. Questiomycin A can be used in research on biological control of cancer and plant diseases[1][2].
Target	GRP78, bacterial.
Invitro	Questiomycin A (3 µM; 24 h) 在 HepG2 细胞中，诱导细胞死亡并下调 GRP78 蛋白的表达[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Questiomycin A 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	Questiomycin A (10 mg/kg; i.p.; once a day for 8 days) 在小鼠模型中，通过降解 GRP78 蛋白以增强 Sorafenib 的抗肿瘤活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	1916-59-2
Formula	C12H8N2O2
Molar Mass	212.20
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Machihara K, et al. Questiomycin A stimulates sorafenib-induced cell death via suppression of glucose-regulated protein 78. Biochem Biophys Res Commun. 2017 Oct 7;492(1):33-40. [2]. Guo S, et al. Production of Antibacterial Questiomycin A in Metabolically Engineered Pseudomonas chlororaphis HT66. J Agric Food Chem. 2022 Jun 29;70(25):7742-7750.

Rotigotine Hydrochloride (Standard)

Posaconazole (Standard)