| Bioactivity | QR-0217 is a potent Aβ1-40 aggregation inhibitor with an IC50 value of 7.5 µM. QR-0217 inhibits α-synuclein aggregation. QR-0217 reduces memory impairments caused by Aβ neurotoxicity[1]. |
| Target | IC50:7.5 µM (Aβ1-40) |
| Invitro | QR-0217 (20、100 µM；96 小时) 抑制 α-突触核蛋白 (4 μM) 聚集[1]。QR-0217 (50 µM) 显着挽救 APP/PS1 转基因小鼠海马体切片中 LTP 的损伤[1]。 |
| Name | QR-0217 |
| CAS | 1027786-12-4 |
| Formula | C19H13NO3 |
| Molar Mass | 303.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Michael D. Carter, et al. Compounds and methods for treating protein folding disorders. US8362066B2. |